Potent, human clinical supported natural antioxidant to reduce oxidative stress and related metabolic conditions in overweight populations.

POWERFUL POLYPHENOL-RICH ANTIOXIDANT

Select, synergistic polyphenols standardized to

≥ 90% Flavonoids

Nature Meets Science

In Vivo Study Results Show SophorOx® Provides Significant
Support Responding to Pro-Inflammatory Cytokines
In Vitro SophorOx® Study Published In The Journal of Integrative and Complementary Medicine Click Here

Methods: The analysis was performed in a cell-based assay using RAW 264.7 macrophage cell line. SophorOx® was screened for cytotoxicity using 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to obtain optimum concentrations for experimental assays. SophorOx® was measured for pro-inflammatory cytokine levels (TNF-α & IL-6) and nitric oxide (NO) levels. Additionally, ROS (reactive oxygen species) levels in RAW cells were estimated using a cell-permeant reagent 2′7′-dichlorofluorescein diacetate (DCFH-DA).

Results: SophorOx® at 10 μM concentration, exhibited an anti-inflammatory property with significant inhibitory levels of TNF-α (∼28.25%) and IL-6 (∼32.25%). SophorOx® at similar concentrations reduced nitric oxide levels to 70.55% in lipopolysaccharide (LPS) stimulated RAW 264.7 cells. Raw 264.7 cells stimulated with LPS exhibited a significant increase in intracellular ROS and this was significantly reduced (78.2% reduction) at lower concentrations (0.3 μM) of SophorOx®.

SophorOx® Human Clinical Study

SophorOx® significantly Reduced Oxidative Stress 600% (6x) as measured by Isoprostane, a reliable biomarker of lipid peroxidation, which is used to indicate antioxidant deficiency and oxidative stress.

Learn more about how SophorOx® can add scientifically supported clean label, botanical function to your brand.

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Proven Applications

Consumer Segments

  • Healthy Agers
    • • By 2050, 1 in 5 people will be age 60 years or over. [un.org] Aging populations with disposable incomes seek preventative
      strategies to live longer, healthier lives.
    • • Opportunities: Joint health, inflammation, cognition, eye health, cardiovascular, skin, and more
  • Millennials & Younger Generations
    • • This segment is keenly aware of the importance of preventative health as they observe the healthy aging segment (often their parents).
  • Sport Set
    • • Strain on body leads to oxidative stress. Antioxidants are increasingly popular with athletes and fitness enthusiasts.
  • Gamers, Workers, & Students
    • • Good vision and brain health are central to a healthy lifestyle and antioxidants can help maintain good vision and brain health.
  • Allergies
    • • Warmer weather from climate change contributes to longer pollen seasons and more potent pollen.
  • Weight Management
    • • This segment experiences higher oxidative stress.
  • Pet Applications
    • • 67% of US households own a pet (APPA 2020) and consumers are increasingly looking for functional, natural ingredients for pets including top pet ailments related to joint pain, inflammation and allergies.

Certifications

  • Non GMO Verified
  • Plant Based
  • Vegan
  • Allergen Free
  • Gluten Free
  • Kosher
  • Halal
  • cGMP
  • NASC
  • Sustainably Sourced
  • Scientifically Proven

Trusted By

Layn Natural Ingredients is the global, manufacturer-direct leader
in the production and innovation of premium plant-based functional ingredients.
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